Lack of replication of association between GIGYF2 variants and Parkinson disease
Identifieur interne : 000876 ( Main/Exploration ); précédent : 000875; suivant : 000877Lack of replication of association between GIGYF2 variants and Parkinson disease
Auteurs : Jose Bras ; Javier Simn-Snchez ; Monica Federoff ; Ana Morgadinho ; Cristina Januario ; Maria Ribeiro ; Luis Cunha ; Catarina Oliveira ; Andrew B. SingletonSource :
- Human Molecular Genetics [ 0964-6906 ] ; 2009-01-15.
Abstract
Mutations in GIGYF2 have recently been described as causative of Parkinson's disease in Europeans. In an attempt to replicate these results in independent populations, we sequenced the entire coding region of GIGYF2 in a large series of Portuguese and North American samples. We report the finding of two of the previously published mutations in neurologically normal Control individuals. This suggests that mutations in GIGYF2 are not strongly related to the development of the disease in either of these populations.
Url:
DOI: 10.1093/hmg/ddn340
Affiliations:
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Singleton</name><affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation><affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation><affiliation><wicri:noCountry code="no comma">E-mail: singleta@mail.nih.gov</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Human Molecular Genetics</title><idno type="ISSN">0964-6906</idno><idno type="eISSN">1460-2083</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2009-01-15">2009-01-15</date><biblScope unit="volume">18</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="341">341</biblScope><biblScope unit="page" to="346">346</biblScope></imprint><idno type="ISSN">0964-6906</idno></series><idno type="istex">E6D5B925B9B23B73826E64DB50201FD5BB9CFD14</idno><idno type="DOI">10.1093/hmg/ddn340</idno><idno type="ArticleID">ddn340</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0964-6906</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Mutations in GIGYF2 have recently been described as causative of Parkinson's disease in Europeans. In an attempt to replicate these results in independent populations, we sequenced the entire coding region of GIGYF2 in a large series of Portuguese and North American samples. We report the finding of two of the previously published mutations in neurologically normal Control individuals. This suggests that mutations in GIGYF2 are not strongly related to the development of the disease in either of these populations.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Bras, Jose" sort="Bras, Jose" uniqKey="Bras J" first="Jose" last="Bras">Jose Bras</name><name sortKey="Cunha, Luis" sort="Cunha, Luis" uniqKey="Cunha L" first="Luis" last="Cunha">Luis Cunha</name><name sortKey="Federoff, Monica" sort="Federoff, Monica" uniqKey="Federoff M" first="Monica" last="Federoff">Monica Federoff</name><name sortKey="Januario, Cristina" sort="Januario, Cristina" uniqKey="Januario C" first="Cristina" last="Januario">Cristina Januario</name><name sortKey="Morgadinho, Ana" sort="Morgadinho, Ana" uniqKey="Morgadinho A" first="Ana" last="Morgadinho">Ana Morgadinho</name><name sortKey="Oliveira, Catarina" sort="Oliveira, Catarina" uniqKey="Oliveira C" first="Catarina" last="Oliveira">Catarina Oliveira</name><name sortKey="Ribeiro, Maria" sort="Ribeiro, Maria" uniqKey="Ribeiro M" first="Maria" last="Ribeiro">Maria Ribeiro</name><name sortKey="Simn Snchez, Javier" sort="Simn Snchez, Javier" uniqKey="Simn Snchez J" first="Javier" last="Simn-Snchez">Javier Simn-Snchez</name><name sortKey="Singleton, Andrew B" sort="Singleton, Andrew B" uniqKey="Singleton A" first="Andrew B." last="Singleton">Andrew B. 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